A fact is a simple statement that everyone believes. It is innocent, unless found guilty. A hypothesis is a novel suggestion that no one wants to believe. It is guilty, until found effective.
Edward Teller

As has repeatedly been stated, the underlying hypothesis, which in a number of cases has been supported by direct experimental evidence, is that each gene controls the production, function, and specificity of a particular enzyme.
Edward Lawrie Tatum

Don't confuse hypothesis and theory. The former is a possible explanation; the latter, the correct one. The establishment of theory is the very purpose of science.
Martin H. Fischer

Even if it had not been possible to reproduce the disease in animals and consequently to verify the hypothesis, this simple observation would have been sufficient to demonstrate the way in which the disease was propagated.
Charles Jules Henry Nicole

From the standpoint of observation, then, we must regard it as a highly probable hypothesis that the beginnings of the mental life date from as far back as the beginnings of life at large.
Wilhelm Wundt

God is not a hypothesis derived from logical assumptions, but an immediate insight, self-evident as light. He is not something to be sought in the darkness with the light of reason. He is the light.
Abraham Joshua Heschel

I am not here concerned with intent, but with scientific standards, especially the ability to tell the difference between a fact, an opinion, a hypothesis, and a hole in the ground.
Serge Lang

I cannot give any scientist of any age better advice than this: the intensity of a conviction that a hypothesis is true has no bearing over whether it is true or not.
Peter Medawar

I long ago suggested the hypothesis, that in the basin of the Thames there are indications of a meeting in the Pleistocene period of a northern and southern fauna.
Charles Lyell

If I were to awaken after having slept for a thousand years, my first question would be: Has the Riemann hypothesis been proven?
David Hilbert

If the facts are contrary to any predictions, then the hypothesis is wrong no matter how appealing.
David Douglass

In choosing a hypothesis there is no virtue in being timid. I clearly would have been burned at the stake in another age.
Thomas Gold

In order to shake a hypothesis, it is sometimes not necessary to do anything more than push it as far as it will go.
Denis Diderot

In writing the history of a disease, every philosophical hypothesis whatsoever, that has previously occupied the mind of the author, should lie in abeyance.
Thomas Sydenham

It is a good morning exercise for a research scientist to discard a pet hypothesis every day before breakfast. It keeps him young.
Konrad Lorenz

It is absolutely essential that one should be neutral and not fall in love with the hypothesis.
David Douglass

It is an hypothesis that the sun will rise tomorrow: and this means that we do not know whether it will rise.
Ludwig Wittgenstein

It would be very discouraging if somewhere down the line you could ask a computer if the Riemann hypothesis is correct and it said, 'Yes, it is true, but you won't be able to understand the proof.'
Ronald Graham

Nevertheless, as is a frequent occurrence in science, a general hypothesis was constructed from a few specific instances of a phenomenon.
Sidney Altman

Not as a demonstrated natural law, but as a working hypothesis.
Henry Norris Russell